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Photo of Dr. Jun Lin 


Dr. Jun Lin







Ph.D., 1998, Animal  Science, The Ohio State University

M.S., 1994, Molecular Microbiology & Immunology, Fudan University, P.R. China

B.S., 1991, Microbiology, Fudan University, P.R. China

Appointment: 91% Research | 9% Teaching

Photo Collage for Dr. Lin 

Professional Interest:  Infectious Diseases/Food Safety

My research program is primarily focused on molecular mechanisms of bacterial pathogenesis and drug resistance, which would reveal potential targets for development of novel intervention strategies and diagnostic tools against pathogens important in animal health and food safety. In addition, I have long-term interest in intestinal microbiota with emphasis on the discovery of microbiome target for enhanced animal production and human health.  Specifically, in the past, I have used fundamental and contemporary approaches to study Campylobacter jejuni, the leading foodborne human pathogen causing enteritis in the United States and many other industrialized countries. Given that poultry are the major reservoir of C. jejuni, on-farm control of C. jejuni is urgently needed to reduce human exposure and the number of foodborne illness in the U.S. To this end, we have established following four identifiable research programs: 1) High-affinity iron acquisition in Campylobacter; 2) Development and evaluation of novel Campylobacter vaccines; 3) Molecular basis and regulation of antimicrobial peptide resistance in Campylobacter; and 4) Beta-lactam resistance mechanisms in Campylobacter. In addition, I also successfully established a collaborative and multidisciplinary research program focused on the effect of antibiotic growth promoter on intestinal microbiota using chicken model, which ultimately may lead to novel “One Health” measure for enhanced animal production, food safety, and human health.  

Selected Publications  

  • Zeng, X., B. E. Gillespie, and J. Lin.  2015.  Important role of a putative lytic transglycosylase Cj0843 in â-lactam resistance in Campylobacter jejuni.  Frontiers in Microbiology (section Antimicrobials, Resistance and Chemotherapy), 6:1292. DOI:10.3389/fmicb.2015.01292.

  • ​Zeng, X., D. Ardeshna, and J. Lin.  2015.  Heat shock enhanced conjugation efficiency in standard Campylobacter jejuni strains.  Applied and Environmental Microbiology, 81:4546-4552.

  • Zeng, X., S. Brown, B. Gillespie, J. Lin. 2014. A single nucleotide in promoter modulates the expression of the β-lactamase OXA-61 in Campylobacter jejuni.  Journal of Antimicrobial and Chemotherapy. 69:1215-1223. DOI:10.1093/jac/dkt515

  • Smith, K., X. Zeng, J. Lin. 2014. Discovery of bile salt hydrolase inhibitors using an efficient high-throughput screening system.  PLOS One 9(1):e85344. DOI: 10.1371/journal.pone.0085344

  • Zeng, X., F. Xu, Y. Mo, and J. Lin. 2013.  Identification and characterization of a periplasmic trilactone esterase, Cee, revealed a unique pathway of ferric enterobactin acquisition in Campylobacter. Molecular Microbiology. 87(3): 594-608.

  • Lin, J., A.A. Hunkapillar, A.C. Layton, Y. Chang, K.R. Robbins. 2013. Response of intestinal microbiota to antibiotic growth promoters in chickens. Foodborne Pathogens and Diseases. 10(4): 331-337

  • Wang, Z., X. Zeng, Y. Mo, K. Smith, J. Lin. 2012. Identification and characterization of a bile salt hydrolase for developing novel alternatives to antibiotic growth promoters.  Applied and Environmental Microbiology. 78:8795-8802.

Book Chapters

  • Zeng, X., and J. Lin. 2014. Siderophore-mediated iron acquisition for Campylobacter infection. Chapter 10. Pp111- 124 In S. Sheppard and G. Meric (eds), Campylobacter Ecology and Evolution. Caister Academic Press, Norfolk, U.K.

  • J. Lin, M. Akiba, and Q. Zhang. 2004. Multidrug efflux systems in Campylobacter. Pp205-218 In M.E. Konkel (ed), Campylobacter:Molecular and Cellular Biology. Horizon Scientific Press, Wymondham, U.K. 

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