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Dr. Marc Caldwell

Assistant Professor



ANSC 515- Special Topics Mitigating Animal Pain-Stress (spring)


2407 River Drive
C222 Veterinary Medical Center
Knoxville, Tennessee 37996
Phone: (865) 974-5703
email: mcaldwell@utk.edu


Ph.D., Biomedical Sciences, Auburn University, 2015

D.V.M., Auburn University, 2006

B.S., Zoology, Auburn University, 2002

Appointment: Large Animal Clinical Sciences


Professional Interest: Infectious Diseases of Livestock, Immunology, Bovine

Respiratory Disease Development, Diagnosis and Clinical Management
Pain in Livestock

Dr. Caldwell focuses his research efforts in the area of livestock infectious diseases, particularly bovine respiratory disease or “shipping fever”. He has broad clinical interests beyond this major focus that also includes lameness in food animals, herd disease or outbreak investigation, and pain management in food animals. He has developed a Mannheimia haemolytica and Bovine Viral Diarrhea Virus infection models that replicate the clinical aspects of bovine respiratory disease and used this model to study shifts in the nasal commensal population of weaned calves, respiratory disease therapeutics, clinical illness behavior in cattle, and improved respiratory diagnostics. In addition, through his role as a food animal field service veterinarian he provided direct support for livestock producers and veterinarians in the state of Tennessee through on-farm care of livestock and delivery up-to-date continuing education and advice to support the day the day management of their farms. Currently, he has 3 graduate students; Dr. Samantha Collins, Dr. Andrea Lear, and Dr. Amber Moore. Dr. Collins is investigating, through metagenomics analysis, the impact of stress and colonization with Mannheimia haemolytica on the commensal nasal bacterial population and how that leads to the development of bovine respiratory disease. Dr. Lear is investigating maternal-fetal immunity in the face of viral infection. She is utilizing a BVDV ¬in utero infection model in pregnant sheep. Dr. Moore is studying the mitigation of post-operative soft tissue pain in adult lactating dairy cattle through NSAID therapy.   


Selected Publications

  • Woodrow JS, Caldwell M, Cox S, Hines M, Credille BC. Comparative plasma pharmacokinetics of ceftiofur sodium and ceftiofur crystalline free acid in neonatal calve. Vet Pharmacol Ther. 2015; doi: 10.1111/jvp.12275. Corresponding author.  

  • Caldwell M, Passler T, Purohit RC, Pascoe D, Wolfe DF. High definition thermal and nuclear scintigraphic imaging assisted diagnosis of lumbosacral discospondylosis in a bucking bull. JAVMA. 2017; 250(5): 464 – 560.   

  • Collins SL, Caldwell M, Whitlock, BK. Comparison of head trauma induced by penetrating and non-penetrating captive bolt in horned goats. AJVR.2017 Feb;78(2):151-157. Corresponding Author.  

  • Eberhart N, Storer J, Caldwell M, Saxton A, Krawczel P. Behavioral and physiological changes in dairy steer calves infected with Mannheimia haemolytica. AJVR.2017 Sept; 78(9). Corresponding Author.