Assistant Professor
Ph. D., University of Illinois at Urbana-Champaign
 
Primary Affiliation: UT FST
Research Area: Food Chemistry and Food Bioactives
 
Professional Preparation
 
BS Food Technology, University of the Philippines Los Banos, 2001
 
MS Food Science, University of the Philippines Los Banos, 2005
 
Ph D Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, 2011
 
Appointments
 
2015 to present, Assistant Professor, Department of Food Science and Technology, The University of Tennessee Knoxville, TN
 
2011 to 2015, Postdoctoral Research Associate, Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign
 
Publications
 
Research Articles
 
Dia VP, Wang Z, West M, Singh V, West L, Gonzalez de Mejia E. 2015. Processing method and corn cultivar affected anthocyanin concentration from dried distillers’ grains with solubles.  DOI: 10.1021/acs.jafc.5b00128.
 
Johnson J., Dia VP, Wallig M, Gonzalez de Mejia E. 2015. Luteolin and gemcitabine protects against pancreatic cancer in an orthotopic mouse model. Pancreas. 44: 144-151.
 
Montoya-Rodriguez A, Milan-Carillo J, Dia VP, Reyes-Moreno C, Gonzalez de Mejia E. 2014. Pepsin-pancreatin protein hydrolysates from extruded amaranth inhibit markers of atherosclerosis in LPS-induced THP-1 macrophages-like human cells by reducing expression of proteins in LOX-1 signaling pathway. Proteome Science. 12:30.
 
Montoya- Rodriguez A, Gonzalez de Mejia E, Dia VP, Reyes-Moreno C, Milan-Carillo J. 2014. Extrusion improved the anti-inflammatory effect of amaranth (Amaranthus hypochondriacus) hydrolysates in LPS-induced human THP- 1 and mouse RAW 264.7 macrophages by preventing activation of NF-κB signaling. Molecular Nutrition and Food Research. 58: 1028-1041.
 
Luna Vital D, Loarca Pina GF, Dia VP, Gonzalez de Mejia. 2014. Differential gene expression of HCT116 and RKO human colorectal cancer cells in response to peptide extracts from common bean (Phaseolus vulgaris L.) non-digestible fraction. Food Research International. 62C: 193-204.
 
Luna Vital D, Gonzalez de Mejia E, Dia VP, Loarca Pina GF. 2014. Peptide extracts of common bean (Phaseolus vulgaris) non-digestible fraction with antiproliferative effect on human colorectal cancer increased expression of p-p53 Ser392 in vitro. Food Chemistry. 157: 347-355.
 
Dia VP, Bringe N, Gonzalez de Mejia E. 2014. Peptides in pepsin-pancreatin hydrolysates in commercially available soy products that inhibit lipopolysaccharide-induced inflammation in macrophages. Food Chemistry. 152: 423-431.
 
Dia VP, de Mejia E. 2013. Potential of lunasin orally-administered in comparison to intraperitoneal injection to inhibit colon cancer metastasis in vivo. Journal of Cancer Therapy. 4: 34-43.
 
Puangpraphant S, Dia VP, de Mejia E, Garcia G, Berhow M, Wallig, M. 2013. Yerba mate tea and mate saponins prevented azoxymethane-induced inflammation of rat colon through suppression of NF-κB p65ser311 signaling via IκB-α and GSK- 3β reduced phosphorylation. BioFactors. 39: 430-440.
 
Dia VP, Frankland-Searby S, Laso del Hierro F, Garcia G, de Mejia E. 2013. Structural property of soybean lunasin and development of a method to quantify lunasin in plasma using an optimized immunoassay protocol. Food Chemistry. 138: 334-341.
 
Vernaza MG, Dia VP, Gonzalez de Mejia E, Chang YK. 2012. Antioxidant and anti-inflammatory properties of germinated and hydrolysed Brazilian soybean flours. Food Chemistry. 134: 2217-2225.
 
Dia VP, Gomez T, Vernaza G, Berhow M, Chang YK, de Mejia, EG. 2012. Bowman-Birk and Kunitz protease inhibitors among antinutrients and bioactives modified by germination and hydrolysis in Brazilian Cultivar BRS 133. Journal of Agricultural and Food Chemistry. 60: 7886-7894.
 
Cavazos A, Morales E, Dia VP, Gonzalez de Mejia, E. 2012. Analysis of lunasin in commercial and pilot plant produced soybean products and an improved method of lunasin purification. Journal of Food Science. 77: C539-C545.
 
Dia VP, Gonzalez de Mejia, E. 2011. Lunasin potentiates the effect of oxaliplatin preventing outgrowth of colon cancer metastasis, binds to α5β1 integrin and suppresses FAK/ERK/NF-κB signalling. Cancer Letters. 313: 167-180.
 
Dia VP, Gonzalez de Mejia, E. 2011. Differential gene expression of RAW 264.7 macrophages in response to the RGD peptide lunasin with and without lipopolysaccharide stimulation. Peptides. 32: 1979-1988.
 
Oseguera-Toledo ME, Gonzalez de Mejia E, Dia VP, Amaya-Llano SL. 2011. Common bean (Phaseolus vulgaris L.) hydrolysates inhibit inflammation in LPS-induced macrophages through suppression of NF-κB pathways. Food Chemistry. 127: 1175-1185.
 
Dia VP, Gonzalez de Mejia, E. 2011. Lunasin induces apoptosis and modifies the expression of genes associated with extracellular matrix and cell adhesion in human metastatic colon cancer cells. Molecular Nutrition and Food Research. 55: 623-634.
 
Cuevas-Rodriguez EO, Dia VP, Yousef G, Garcia-Saucedo PA, Lopez-Medina J, Paredes-Lopez O, Gonzalez de Mejia E, Lila M. 2010. Inhibition of pro-inflammatory responses and antioxidant capacity of Mexican blueberry (Rubus spp.) extracts. Journal of Agricultural and Food Chemistry. 58: 9542-9548.
 
Dia VP, Gonzalez de Mejia. 2010. Lunasin promotes apoptosis in human colon cancer cells by mitochondrial pathway activation and induction of nuclear clusterin expression. Cancer Letters. 295: 44-53.
 
Gonzalez de Mejia E, Wang W, Dia VP. 2010. Lunasin with an arginine-glycine-aspartic acid motif causes apoptosis to L1210 leukemia cells by activation of caspase-3. Molecular Nutrition and Food Research. 54: 406-414.
 
de Mejia EG, Dia VP. 2009. Lunasin and lunasin-like peptides inhibit inflammation through suppression of NF-kB pathway in the macrophage. Peptides. 30: 2388-2398
 
Dia VP, Torres S, de Lumen BO, Erdman JW, Gonzalez de Mejia E. 2009. Presence of lunasin in plasma of young men after soy protein consumption. Journal of Agricultural and Food Chemistry. 57 (4): 1260-1266.
 
Martinez-Villaluenga C, Dia VP, Berhow M, Bringe NA, Gonzalez de Mejia E. 2009. Protein hydrolysates derived from soybean genotypes enriched in β-conglycinin inhibit lipid accumulation and inflammation in vitro. Molecular Nutrition and Food Research. 53: 1007-1018.
 
Dia VP, Wang W, Oh V, de Lumen BO, Gonzalez de Mejia, E. 2009. Isolation, purification and characterisation of lunasin from defatted soybean flour and in vitro evaluation of its anti-inflammatory activity. Food Chemistry. 114 (1): 108-115.
 
Dia VP, Berhow M, Gonzalez de Mejia E. 2008. Bowman-Birk inhibitor and genistein among soy compounds that synergistically inhibit nitric oxide and prostaglandin E2 pathways in lipopolysaccharide-induced RAW 264.7 macrophages. Journal of Agricultural and Food Chemistry. 56 (24): 11707-11717.
 
Wang W, Dia VP, Vasconez M, Nelson R, Gonzalez de Mejia E. 2008. Analysis of soybean protein-derived peptides and the effect of cultivar, environmental conditions, and processing conditions on lunasin concentration in soybean and soybean products. Journal of AOAC International. 91 (4): 936-946.
 
Dia VP, VV Garcia, RC Mabesa and EM Tecson-Mendoza. 2005. Comparative Physicochemical Characteristics of Virgin Coconut Oil Produced by Different Methods. Philippine Agricultural Scientist 88 (4):462-475.
 
Review Paper
 
Gonzalez de Mejia E, Dia VP. 2010. The role of nutraceutical proteins and peptides in apoptosis, angiogenesis and metastasis of cancer cells. Cancer Review Metastasis. 29: 511-528.
 
Book Chapters
 
Mojica L, Dia VP, Gonzalez de Mejia E. Soy Proteins, In Applied Food Protein Chemistry, Ustunol Z. (ed), pp.
141-192. John Wiley and Sons Ltd. In Press.
 
Oseguera-Toledo M, Dia VP, Gonzalez de Mejia E, Amaya Llano SL. 2012. Bean concentrates and reduction of inflammation, In Hispanic Foods: Chemistry and Bioactive Compounds, Tunic M. and de Mejia EG. (eds),
pp.217-232. American Chemical Society, Retrieved from http://pubs.acs.org.
 
Hernandez-Ledesma B, Hsieh CC, Dia VP, Gonzalez de Mejia E, de Lumen BO. 2011. Lunasin, a cancer
preventive peptide, In Soybean and Health, El-Shemy, HA (ed) pp. 145-166. In Tech, Retrieved
from www.intechopen.com.
 
Gonzalez de Mejia E, Dia VP. 2010. Chemistry and biological properties of soybean peptides and proteins, In
Chemistry, Texture and Flavor of Soy. Cadwallader K et al. (eds), pp. 133-154. American Chemical Society,
Retrieved from http://pubs.acs.org.
 
Laboratory Manual
 
Del Rosario RR, del Rosario OM and Dia VP. 2003. Food Chemistry Laboratory Manual. College of Agriculture
Publications Office, University of the Philippines Los Baños.

 


 
 
 
 
 
 
 
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Contact Dr. Dia
209 Food Science & Technology Building
2510 River Drive
Knoxville, TN 37996-4539
Phone: (865) 974-7265
Fax: (865) 974-7332
Email:vdia@utk.edu